Poster Session 2 — ASN Events

Poster Session 2 — ASN Events

Poster Session 2

SO-HW01, a medicinal plant extract, inhibits inflammasome activation and prevents endotoxin-induced septic shock in mice (#110)

Sang-Myeong Lee

Role of STAT3 in regulation of cancer metabolism (#287)

Inhibition of JAK signalling by SOCS1 (#288)

Nicholas PD Liau

Understanding emergency haematopoiesis using cellular barcoding (#289)

Oncostatin M and IL-6 induce pro-inflammatory gene signatures in articular chondrocytes (#290)

Phosphatase PP4 negatively regulates antiviral innate immune response by dephosphorylating TBK1 in macrophages (#115)

Regulation of STING via the RIG-I dependent RNA sensing pathway (#116)

Targeting interleukin 6 in endothelial cells to prevent undesired formation of new blood vessels (#291)

Liza U Ljungberg

Detection, localisation and quantification of the interaction between IL-37 and its cell surface receptor in human peripheral blood mononuclear cells via dSTORM super-resolution imaging (#292)

IRF-3, IRF-7, and IPS-1 Promote Host Defense against Acute Human Metapneumovirus Infection in Neonatal Mice. (#117)

Small Molecule RIG-I Agonists as Vaccine Adjuvants and Antiviral Therapy (#118)

Regulation of myeloid cell population kinetics and phenotype by CSF-1 and GM-CSF (#293)

Understanding the Role of Pro-inflammatory Cytokines in the Development of Gastric Cancer (#294)

PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model (#119)

Pei Ching (Regine) Low

Therapeutic deletion of IL-17 producing CD8+ T cells (Tc17) attenuates GVHD without impairing GVL. (#295)

Kelli PA MacDonald

The effect of Salsola tuberculata extracts and Compound A against intracellular interleukin-1alpha (icIL-1α) in the UVB in vitro model for inflammation and chemoprevention in skin (#121)

Tandeka Magcwebeba

Intestinal epithelium is an autonomous lambda interferon-dependent cell compartment that is calibrated by intestinal microflora (#122)

Tanel Mahlakoiv

Functional analysis of CISH (Cytokine inducible SH2-containing protein) (#123)

Immunotolerance-inducing IDO-1 and Th1-Cytokines are upregulated in Subcutaneous Panniculitis-like T-cell Lymphoma; signs of an immunosuppressive microenvironment (#124)

Pilvi Maliniemi

A role for interferon epsilon in the innate immune response in the female reproductive tract (#125)

Investigating type I interferon gene signatures in breast cancer patients (#298)

Arid5a enhances the development of Th17 cells by stabilizing Stat3 mRNA (#299)

Possible role of IL-10 in the natural resistance of mouse to leptospirosis (#127)

Modulation of atherosclerosis in ApoE-deficient mice by gp130 signalling. (#128)

Louise E McLeod

Effects of acute fluoride exposure in Substance P myenteric varicosities of the small intestine (#129)

Decidual-trophoblast interactions are critical for maternal tolerance of pregnancy. (#300)

Ellen Menkhorst

Tcf-1 controls innate lymphoid cell differentiation and protection in intestinal inflammation (#130)

Mitochondrial apoptosis is dispensable for NLRP3 activation but non-apoptotic caspase-8 is required for inflammasome priming (#301)

Alison Mildenhall

Clostridium difficile toxin B induces an inflammatory cytokine response in a mouse model of infection (#302)

Pomalidomide disrupts the association between Cereblon and Rabex-5 resulting in the suppression of TLR induced Cytokine production (#131)

Suppressing NLRP3 inflammasome activation by high-affinity stapled-peptides (#132)

Alessandra Mortellaro

Mechanisms of lyssavirus evasion of innate immunity and roles in lethal rabies disease (#133)

Gregory Moseley

Cytokines differentially regulate complement receptor immunoglobulin (CRIg) in human macrophages: a control point in inflammation (#303)

Mycobacterium tuberculosis strains induce differential cytokine production and gene expression patterns in pulmonary alveolar epithelial cells (#135)

Nontobeko E. Mvubu

Candida induces pyroptosis during escape from macrophages (#304)

Cytokine addition slows STAT3 transport to the nucleus as revealed by live cell imaging and fluorescence recovery after photobleaching (#136)

Inhibition of IFN-regulated mediators of the IRF3 signaling pathway using small molecule inhibitors targeting TBK1 (#305)

Understanding the Role of Cytokines in the Onset and Progression of Intestinal-Type Gastric Cancer (#306)

A Two-Site Interaction Underpins TRIM25 Activation of the RIG-I Anti-Viral Response (#307)

Sandra Nicholson

IL-1 receptor antagonist (IL-1Ra) prevents murine bronchopulmonary dysplasia (BPD) induced by perinatal inflammation and hyperoxia. (#309)

Claudia Nold-Petry

Absence of IL-6 accelerates thrombus formation through reduced MMPs and uPA expression in murine deep vein thrombosis model (#138)

Regulation of Th2 cell responses by Grail (#310)

Hck Drives Pulmonary Inflammation via IL-6 and Promotes Alternative Activation of Macrophages and Cancer Progression. (#139)

Robert JJ O'Donoghue

CD141⁺ DC and IFN-λ production in the peripheral blood of a young cohort of injecting drug users (IDUs) with chronic HCV infection (#311)

Meredith O'Keeffe

Loss of NF-κB1 Promotes Gastric Cancer through Cytokine Driven Chronic Inflammation (#312)

Lorraine A O'Reilly

Intracellular interferon lambda 4 (IFN-λ4) induces apoptotic cell death in human hepatic cells (#140)

Olusegun Onabajo

Glutamine treatment attenuates hyperglycemia induced mitochondrial stress and apoptosis in umbilical vein endothelial cells: A relevance in severe sepsis (#141)

Sidt2 is required for innate immunity to extracellular dsRNA (#313)

Possible role of the NLRP3 inflammasome in the development of human atherosclerosis and myocardial infarction. (#314)

Therapeutic peptides from IK cytokine ameliorate rheumatoid arthritis through the suppression of macrophage activation as well as T_H1 and T_H17 cell differentiation (#142)

Nod2 and Rip2 contribute to innate immune responses in mouse neutrophils (#143)

A type III effector antagonises death receptor signaling during bacterial gut infection (#315)

Jaclyn S Pearson

The Pyrimidine Synthesis Modulon: A Stabilised Oscillatory Network Governed by Interferon Signalling. (#316)

Complex regulation of nucleic-acid sensing TLRs by UNC93B1 (#146)

Interferon-β regulates Th17 polarization and dendritic cell migration in EAE (#317)

Leesa M Pennell

The placental derived protein syncytin-1 impairs antiviral responses and exaggerates inflammatory responses to influenza (#147)

Peter PW Peter Wark

THE NOVEL INFLUENZA VIRUS H7N9 PEPTIDE ACTIVATES THE INFLAMMASOME (#149)

Haematopoietic Cell Kinase Activation Promotes IL-11 Dependent Gastric Cancer Progression and Invasion in Mice (#150)

INTERFERON LAMBDA 4 (IFN-λ4) INDUCES A PRO-INFLAMMATORY STATE IN HUMAN HEPATIC CELLS WHICH CAN BE BLOCKED BY A MONOCLONAL ANTIBODY (#151)

Ludmila Prokunina-Olsson

The Interleukin-11 signaling cascade: a promising target for cancer treatment (#319)

CD8 T Cell Responses Correlate with Antigen but Are Independent of Type I IFN and STING Signaling After Adenoviral Vaccination (#152)

The effect of Gelam honey on the oxidative stress induced inflammatory pathways in pancreatic hamster cells (#153)

Novel insights into interferon regulated expression of the c-MYC gene in human cancer (#320)

Stephen J Ralph

IFN-γ and IL-17A drive distinct airway changes in a murine model of steroid-unresponsive severe asthma (#156)

Mahesh Raundhal

Exploiting the type-1 Interferon pathway in the treatment and prediction of breast cancer metastasis (#321)

Versatility of Major Histocompatibility Complex Class II Dextramers for Detection, and Functional Characterization of Antigen-Specific, Autoreactive CD4 T Cells in the Mouse Models of Autoimmune Diseases (#157)

Role of Bacillus infantis NRRL B-14911 in the mediation of autoimmune myocarditis (#323)

Firing from the Inside: Signaling of Oncogenic Gp130 and its Spatial Regulation (#159)

Unveiling a novel immunomodulatory role for Interferon-β therapy in Multiple Sclerosis: the selective reduction of pathogenic memory B cells (#160)

Serum interleukin 38 is associated with disease severity and organ involvement in systemic lupus erythematosus. (#324)

COLONY-STIMULATING FACTOR-1 AND TUMOR NECROSIS FACTOR- α IN ARTHRTIC PAIN (#325)

The RIG-I like receptor pathway: New insights in the subcellular localization of the components (#326)

Maite Sanchez-Aparicio

Determining the source of Type III IFNs (IFNλs) in vivo using a novel IFNλ reporter mouse model (#327)

Marvin J Sandoval

The effects of the association chlorhexidine/propolis on LPS-induced cytokine profile and NF-κB transcription factor activation by human monocytes. (#162)

Karina B. Santiago

Sequence-dependent off-target inhibition of TLR7/8 by synthetic microRNA inhibitors. (#163)

Soroush T. Sarvestani

CSL324, A HUMANISED ANTI G-CSFR ANTIBODY, CAN INHIBIT NEUTROPHIL MIGRATION WHILE NOT IMPACTING ON NEUTROPHIL NUMBER OR EFFECTOR FUNCTIONS (#164)

Karen Scalzo-Inguanti

Type I IFNs display differential antiviral potency in cells with JAK-STAT signaling deficiencies (#328)

William M Schneider

IRF6: a key regulator of oral epithelial cell responses to the human pathogen Porphyromonas gingivalis (#329)

Isocyperol isolated from rhizomes of Cyperus rotundus, inhibits iNOS and pro-inflammatory cytokines through suppressing STAT3 pathway in LPS-stimulated RAW 264.7 cells (#166)

Changes in RNA expression pattern in neutrophils of patients with Indian Visceral leishmaniasis (#330)

Interleukin-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting interleukin-1 signal on macrophages (#331)

Local overproduction of IL10 in astrocyte targeted IL10Tg mice modulates microglial response by modulating regulatory receptors TREM2 and CD200R following perforant pathway transection. (#332)

Kalpana Shrivastava

Host and Viral 2’,5’-Phosphodiesterases Antagonize DsRNA Signaling to RNase L During Antiviral Innate Immunity (#167)

Robert H. Silverman

IRF8 and IRF3 cooperatively regulate rapid interferon-β induction in human blood monocytes (#168)

IL-19, a novel SASP factor, is upregulated during senescence and in response to DSBs (#169)

Mechanisms behind immunoregulatory effects of probiotic yeasts (#170)

Impact of microbiota on expression of mRNA of NF-kappa B family molecules in the intestine of germ-free and conventional piglets (#172)

Probiotics in a gnotobiotic piglet model of preterm infants (#173)

Alla Splichalova

Transgenic mice expressing interferon-regulated human influenza virus restriction factor MxA (#174)

Interleukin-13 predisposes mice to more severe influenza infection by suppressing interferon responses and activating microRNA-21/PI3K (#175)

Malcolm Starkey

miR-17~92 and it’s role in inflammation and innate immune signalling. (#176)

James H Stunden

The NLRP3 inflammasome is regulated by phosphorylation and ubiquitinylation (#177)

Strawberry notch homolog 2 is a novel nuclear IL-6 primary response gene in glial cells (#334)

Leucine-rich α2 glycoprotein promotes TGFβ1-induced apoptosis in the lewis lung carcinoma cell lines (#178)

Norihiko Takemoto

IFNγ and Smac mimetics induce synergistic killing via necroptosis and apoptosis (#179)

Elucidation and characterization of CD4⁺TCRγδ⁺ FoxP3⁺ type of immune-suppressive cells with the progression of leprosy. (#180)

Ifnar2 plays an important role in limiting inflammation and disease following influenza virus infection (#181)

Michelle D Tate

The leukocyte immunoglobulin-like receptor B4 differentially regulates FcγRI-dependent TNF production via its three intracellular immunoreceptor tyrosine-based inhibitory signalling motifs (ITIMs). (#182)

Nicodemus Tedla

Characterizing the Molecular Players Involved in Lipopolysaccharide Inflammatory Responses (#336)

Elizabeth J Thatcher

Glucocorticosteroids dampen anti-viral defences and enhance the replication of respiratory viruses (#184)

Belinda J Thomas

Characterisation of human metapneumovirus infection of primary human bronchial cells (#337)

Belinda J Thomas

A flow cytometric assay for ASC speck formation in inflammasome responses (#338)

Sara J Thygesen

Dealing With 'Cytokine Storms': A Cultural and Linguistic Translation of Warm Factor Epidemics Wenbing as Seasonal Viral Influenza Epidemics in Australia (#185)

Mast cell differentiation is operated by a T cell response (#339)

Shota Toyoshima

Apoptotic Cell Recognition Receptors, TYRO3, AXL and MER (TAM), Demonstrate Distinct Patterns and Complex Regulation of Ligand-Induced Activation and Signaling (#340)

CD4+ T-cell maturation and activation state dictate the impact of STAT3 mediated IL-6 induced changes in the transcriptome. (#186)

West Nile virus (WNV) infection alters the cytokines and TLRs transcriptome profiles in rabbit PBL (#187)

Poor outcome in rheumatoid arthritis patients switching from etanercept to tocilizumab therapy (#341)

Procaspase-8 recruitment and activation at the AIM2 inflammasome (#342)

Parimala Vajjhala

Lung parenchyma–derived IL-6 promotes IL-17A–dependent acute lung injury after allogeneic stem cell transplantation. (#188)

Antiopi Varelias

DYSTONIA-CAUSING FRAME-SHIFT MUTATION IN PACT ACTIVATES INTERFERON-INDUCED PROTEIN KINASE PKR BY AGGREGATE FORMATION (#343)

Lauren S Vaughn

Investigating how the immunosuppressant Cyclosporin A inhibits NLRP3 inflammasome activation (#190)

Swarna Lekha Vijayaraj

ASTROCYTE-TARGETED PRODUCTION OF IL-10 INDUCES CHANGES IN MICROGLIAL REACTIVITY AND REDUCES MOTOR NEURON DEATH AFTER FACIAL NERVE AXOTOMY (#345)

Nàdia Villacampa

Impaired Antigen Presentation Following Systemic Inflammatory Response Syndrome (SIRS) is Caused by the Local Induction of a Paralysis Program in Developing Dendritic Cells (#191)

Jose A Villadangos

Inhibitor of apoptosis (IAP) proteins ubiquitylate RIP3 kinase and repress apoptosis, necroptosis, NLRP3 inflammasome activation and systemic inflammation (#193)

Cytoplasmic DNA induces rapid cell death in Drosophila cells (#346)

Leptin And IL-17 Mediated Responses In Vaccination Against Helicobacter pylori. (#194)

Regulatory T cells and Cyclic Adenosine Monophosphate in Enterovirus 71 Infection (#195)

Regulation of embryonic hematopoiesis by a cytokine inducible SH2-domain (CISH) homologue in zebrafish (#348)

Critical role of cytokine and growth factor receptors in AML identified using an RNAi functional screen (#349)

Kevin M Watanabe-Smith

Critical role for IL-33 in the onset and progression of experimental asthma induced by concomitant virus infection and allergen exposure (#196)

Rhiannon B Werder

Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection (#350)

Inflammation and Nitric Oxide Synthase 2 in driving poor prognosis in Era(-) Breast Cancer (#198)

Cytokine profiles of chronic fatigue syndrome and multiple sclerosis patients (#199)

Regulation of G-CSF and its receptor in skeletal muscle in response to exercise-induced damage in vivo and LPS stimulation in vitro (#200)

Casine kinase II is a novel regulator of TBK1/IRF3 and type I interferon induction by various innate receptors (#201)

Interferon regulator factor (IRF) 8 regulates the microglial response to neuronal injury (#202)

The BTB-ZF transcriptional regulator, PLZF, modifies chromatin to restrain inflammatory cytokines signaling programs (#352)

Endogenous matrix metalloproteinase (MMP)-9, and not MMP-2, promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation (#203)

Regulatory Effect of Interleukin-4 in the Innate Immune and Inflammatory Responses to Rhodococcus aurantiacus Infection in Mice (#204)

A role for Protein Kinase R in regulating NLRP3 inflammasome assembly (#205)

Significant Association of a Genetic Variant in IL-37 with Coronary Artery Disease in the Chinese Han Population (#206)

Pronuclear injection of circular plasmids expressing hCas9 and gRNA generates mutant mice in genes involved in immune responses. (#353)

Mycobacterium tuberculosis-derived mycolic acid shows an adjuvant activity by activation of the ITAM receptor/CARD9-mediated innate immunity (#207)

Brain derived neurotrophic factor regulated immune responses in vivo (#354)

Yasuhiro Yoshida

STAT3-driven regulation of microRNAs during gastric inflammation-associated tumourigenesis (#209)

Exploring NLRP12 – an emerging member of NOD-like receptor family (#210)

Alina Zamoshnikova

Kupffer cell derived IL-1a promotes acetaminophen-induced liver injury (#355)

A New Era of Interferon Studying (#211)

MAP kinase phosphatase 5 expression induced by influenza virus infection negatively regulates IRF3 activation and type I interferon response (#212)

Yongliang Zhang