An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression — ASN Events
  1. Schedule
  2. Poster Session 1
  3. An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression

An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression (#271)

Haiyoung Jung 1 2 , Young-Ju Kang 1 , Arum Park 1 2 , Young-Jun Park 1 2 , Tae-Don Kim 1 2 , Inpyo Choi 1 2 , Suk Ran Yoon 1 2
  1. KRIBB, 125 Gwahak-ro, Yuseong-gu, South Korea
  2. Functional Genomics, UST, Deajeon, South Korea

Endometriosis is known to be related to a defect in NK cell cytolytic activity. Additionally, the levels of inflammatory cytokines are elevated in the peritoneal fluid (PF) of women with endometriosis. Here, we show the decrease of natural killer (NK) cell cytolytic activity in the PF of endometriosis patients by primary cytokine activity. An increased level of interleukin-6 (IL-6) in the PF of patients with endometriosis suppresses NK cell cytolytic activity by down-regulating cytolytic granule components, such as granzyme B and perforin, through the modulation of Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2) expression, suggesting that IL-6 plays a crucial role in the reduction of NK cell activity in the PF of patients with endometriosis.