Bats are known to be the natural reservoir hosts of multiple pathogenic viruses with frequent zoonotic spillover events into human populations. However, most virus infections are completely asymptomatic in bats. These same virus infections cause mass-inflammation in animals and humans. We are investigating how pathogen detection and activation of the Interferon signaling pathways, and cross talk to the inflammasome pathway may be altered in the Australian black flying fox. Our data so far suggests that while bats can mount a sufficient, yet altered, induction of the IFN pathway with production of IFN α, β and λ and various ISGs, and induction of NFκB signaling, most pathogen detection does not result in activation of the inflammasome signaling complexes. Interrogation of the inflammasome pathways reveals poor Asc-recruitment and low caspase activation in response to natural and synthetic ligands. Whether this is due to altered kinetics, a decrease in sensitivity or redundancy of signaling pathways is currently under investigation.