Immunological manifestations of autophagy (#S-29)
The broad immunological roles of autophagy span innate and adaptive immunity and are often manifested in inflammatory diseases. The immune effects of autophagy partially overlap with the hub function of autophagy in metabolism and cytoplasmic quality control but typically expand further afield to encompass unique immunological adaptations. One of the best-appreciated manifestations of autophagy is protection against microbial invasion, but this is by no means limited to direct elimination of intracellular pathogens and includes a stratified array of nearly all principal immunological processes. This presentation will provide a broad background to immunological roles of autophagy, highlight a few model examples, and report on the newest development demonstrating that the TRIM family of proteins act as cellular organizers of the core autophagy regulatory machinery and as receptors for selective autophagic elimination of microbial and endogenous cellular targets.