ICIS 2014* IL-1 regulation in inflammatory disease (#S-34)
Inflammation plays vital roles in protective responses against pathogens and tissue repair, however, improper resolution of inflammatory networks is centrally involved in the pathogenesis of many acute and chronic diseases. Extensive advances have been made in recent years to define the inflammatory processes that are required for pathogen clearance, however, in comparison, less is known about the regulation of inflammation in sterile settings. Our recent studies describe the cellular events and molecular signalling pathways regulated by the cytosolic innate immune receptors NLRs and IL-1 that govern inflammation in inflammatory disease.
