Innate immunity is the first line of defense against microbial invasions via a set of pattern-recognition molecules. We have established a powerful cDNA library screening system to search systematically for new genes essential in innate immunity. Using Yeast two hybrid screen, immuno-purification and Mass-spec-based protein identification techniques, we are also interested in identifying new genes in the signal complexes. Current projects in the lab focus on 1) Mechanism through which cells recognize dsDNA. 2) Function of ubiquitination in innate immunity. 3) Mechanisms leading to cytokine production and secretion after infection. 4) Malfunction of innate immunity and related diseases.