Poster Session 1 — ASN Events

Poster Session 1 — ASN Events

Poster Session 1

Characterisation of the function of the Interleukin-11 signaling complex in human disease (#213)

Suad Abdirahman

Generation and characterization of IL-33 cytokine traps as anti-cytokine blockers (#2)

Role of Integrin-linked kinase in innate immunity and in inflammatory diseases. (#3)

HIV infection is associated with altered monocyte subset basal cytokine levels and responsiveness to LPS stimulation. (#215)

Thomas A Angelovich

Characterization of human-restricted TLR4 responses identifies a novel ubiquitin ligase required for NLRP3 inflammasome responses in human macrophages (#216)

Juliana K Ariffin

IL-10 is critical for the expansion of peritoneal and splenic CD5⁺B cells (#217)

Yuriy Baglaenko

Characterization of a Novel Interferon Stimulated Gene with Antiviral Activity (#4)

Corey A Balinsky

The mouse PYHIN protein P207 regulates transcription of TNF (#5)

Development of new automated technology for the detection and analysis of pathogenic autoantibodies in autoimmune disease (#219)

Elevated hMPV, but not RSV, replication in the nasal epithelium of asthmatic adults is facilitated by an IFN-independent integrated stress response (#6)

T cell help amplifies innate signals required for efficient CTL priming (#7)

RAGE is a cell surface nucleic acid sensor (#9)

Damien Bertheloot

Correlation and kinetics of IFN-gamma and TNF-alpha transcription and translation in lymphocyte subsets using the FlowRNA assay and intracellular antibody staining (#221)

Cell-restricted deletion of MyD88 affects tau pathology in hTau mouse model of tauopathy (#10)

Autocrine CXCL13-CXCR5 signaling potently induces EMT of breast cancer cells via RANKL-Src-PI3Kp110α during lymph node metastasis (#222)

Perinatal exposure to galactooligosaccharides/inulin prebiotics prevent food allergy by protecting intestine and promoting tolerance. (#11)

The rs12971860 C/T SNP in the interferon lambda3 (IL28B) gene influences the expression of thymidine phosphoryase and cytidine deaminase, two enzymatic markers of inflammation (#224)

Sara Bonanzinga

Local IFN-I responses orchestrate cytokine responses and confer protection upon vaccinia virus infection (#12)

Katharina Borst

Crosstalk between interferon-beta, foam cell formation and inflammatory responses (#13)

Marieke C.S. Boshuizen

Spontaneous mutation in TNF in a new model of rheumatoid arthritis (#225)

Philippe Bouillet

F-actin is required for negative regulation of NLRP3 inflammasome activity by Flightless-I and LRRFIP2 (#227)

The role of cytokines in the cerebrospinal fluids of patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) (#15)

Super-resolution microscopy reveals important roles for microtubule bundling by rabies virus P3 protein in immune evasion and disease (#228)

Deregulated gp130/Stat3 signalling in lung cancer development (#16)

The inflammasome adaptor ASC mediates gastric tumourigenesis independent of inflammation (#18)

Alison F Browning

Ellagic acid hydroxypropyl-ß-cyclodextrin inclusion complex alleviates adjuvant-induced arthritis: Attenuation of oxidative stress and inflammatory mediators (#19)

Neutralising anti-G-CSFR monoclonal antibody blocks neutrophil-driven inflammatory joint disease (#20)

Essential function of type I IFN signaling in balancing inflammation during Streptococcus pyogenes infection (#21)

Virginia Castiglia

NOD2 immunity protects against obesity-induced inflammation and insulin resistance. (#22)

Joseph F Cavallari

Palmitoleate reverses palmitate-induced pro-inflammatory macrophage polarization (#23)

Interferon regulatory factor 4 and inflammation (#24)

Hydroxychloroquine activates host antiviral innate immunity (#25)

Tsung-Hsien Chang

An elucidation of the regulation of the Interferon pathway using the Interferome and Enrich bioinformatics resources. (#230)

Murine melioidosis with CNS syndrome induced by CD11bCD62L cells harboring Burkholderia pseudomallei (#26)

IL-6 possibly modulates ghrelin expression through MEK1/ p90RSK signaling cascade in pancreatic cell lines (#27)

Choy-Hoong Chew

Interleukin-37 – An Anti-inflammatory Cytokine for Necrotizing Enterocolitis? (#231)

Frequency of CD36 and CD109 deficiency on platelets : single institute study in Korea (#28)

Bioassay Guided Isolation for Anti-inflammatory and Antioxidant Components from Celastrus paniculatus Seeds. (#29)

Amrita Chowdhury

Undefined region of ectodomain plays a role in determining the activity of TLR8 (#232)

Tsung-Hsien Chuang

West Nile virus sfRNA prevents incorporation of anti-viral molecules into exosomes to facilitate virus spread (#234)

Combined siRNA and TLR-activating therapy for the improved treatment of viral infections. (#235)

Daniel T.W. Clarke

Cleavage and Secretion of Interleukin-1b in the Absence of Cell Death. (#236)

Stephanie Conos

The effects of Brazilian propolis on NF-κB transcription factor activation and LPS-induced cytokine production by human dendritic cells (#31)

MCC950 is a potent and specific inhibitor of the NLRP3 inflammasome and a novel therapeutic for NLRP3 driven diseases (#237)

Matthew A Cooper

Discovery of novel selective C5a2 ligands that can modulate IL-6 release from macrophages (#32)

Daniel E Croker

Interferon-α-induced IL-6 improves immune and clinical benefits of regulatory T cell depletion as ovarian cancer immunotherapy (#238)

Tyler J. Curiel

Expression and function of ADAR1 and PACT and their impact on PKR activation during HIV-1 infection (#34)

Oral rapamycin prevents carcinogen and inflammation-induced skin carcinogenesis through an IFN-γ-dependent mechanism (#35)

Pathogenic potential of interferon αβ in acute influenza infection (#239)

Sophia Davidson

Development and characterization of a cell-penetrant IRF5 inhibitor (#240)

Characterizing the role of IRF5 in human B cell development and function (#241)

Role of an IFNAR1-IFNβ mediated signalling axis in immune cells (#242)

Nicole A De Weerd

Indigofera cordifolia seeds attenuate the oxidative stress and inflammation associated with Streptozotocin induced Type 2 Diabetes mellitus (#37)

Padmini Deshpande

Targeting placental leukemia inhibitory factor in vivo with a unique inhibitor as a novel treatment strategy for ectopic pregnancy. (#243)

Evdokia Dimitriadis

An essential role for Interferon-β in the induction of interferon-stimulated gene expression by lipopolysaccharide in macrophages (#38)

Raymond P Donnelly

The effect of Mal D96N SNP in TLR signalling (#39)

Jennifer K Dowling

Induction of IL-6 expression through TLR4 by oxidised phospholipids involves the selective induction of Arid5a but not Regnase-1 expression. (#244)

γβ T cells, a novel T cell subset with a pathogenic role in IL-17-mediated CNS autoimmunity (#41)

Sarah C Edwards

Distinct dictation of Japanese encephalitis virus-induced neuroinflammation and lethality via triggering TLR3 and TLR4 signal pathways (#43)

CD11c^highPDCA-1^int/low dendritic cells regulates the differentiation of CD11b⁺Ly-6C^high monocytes and permeability of blood-brain barrier to galvanize the immune privileged CNS to neuroinflammation (#44)

Functional restoration of exhausted CD4⁺ and CD8⁺ T cells in chronic viral infection by daphnane diterpene ester derived from Daphne genkwa flos buds via negative regulatory Tim-3 molecule (#45)

Distinct upstream role of type I IFN signal to hematopoietic stem cell-derived leukocytes and resident cells for connected recruitment of Ly-6C^high monocytes and NK cells via CCL2-CCL3 cascade to restrict CNS-invasion of herpes simplex virus in mucosal tissues (#46)

Suppressed gp130/Jak/Stat3 cytokine activity blocks WNT signaling-mediated intestinal tumorigenesis and regeneration (#214)

TRAF2 regulates NFĸB transcription factors to inhibit cell death and inflammation in the skin (#47)

IL-2 coordinates IL-2 producing and regulatory T cell interplay (#48)

The pivotal role of interferon gamma (IFNγ) in TLR9-mediated murine models of macrophage activation syndrome (MAS)/secondary hemophagocytic lymphohistiocytosis (sHLH). (#49)

Walter G. Ferlin

Novel insights into IL-6 biology revealed by selective targeting of TRANS-signaling. (#50)

Walter G. Ferlin

Plasmodium berghei ANKA sporozoite infection induces the formation of liver-associated CD8 T cells that resemble tissue resident memory cells (#52)

Daniel Fernandez Ruiz

Small tumor necrosis factor-α receptor (TNFR) biologics selectively inhibit the TNF-p38 signalling axis and inflammation (#248)

Antonio Ferrante

IL-6R blockade: a new personalised treatment for asthma? (#53)

Manuel Ferreira

Helminth-induced innate type-2 cytokines protect against autoimmunity. (#54)

Imidazoquinolines signal through TLR7 and IRF-5 for the production of type I and III interferon in primary human plasmacytoid dendritic cells (#250)

Patricia Fitzgerald-Bocarsly

Comprehensive Integration of RNA and HITS-CLIP Sequencing for fine scale mapping of the Type 1 Interferon Response (#251)

Role of Regulatory T cells in Citrobacter rodentium infection (#59)

Atherosclerosis severity is independent of endogenous IL-33 signaling (#60)

Modulation of RIG-I signalling by OASL (#252)

Hans Henrik Gad

S100A8: a novel immunosuppressive protein (#62)

Do G-CSF and Neutrophils Contribute to the Pathophysiology of Rheumatoid Arthritis? (#254)

Gabrielle Goldberg

G-CSF and Neutrophils are Non-Redundant Mediators of CNS Autoimmune Disease (#255)

Gabrielle L Goldberg

The crystal structure of human interleukin-11: receptor binding site features and structural differences from interleukin-6 (#256)

Michael Griffin

Strawberry notch homolog 2 gene expression is increased in the brain during endotoxin-induced systemic inflammation and is localized to numerous cells including astrocytes and microglia (#257)

Magdalena Grill

Interferon gamma deficiency and Epstein-Barr virus reactivation in the pathogenesis of chronic lymphocytic leukemia (#258)

Ewelina Grywalska

Using Type III Interferon to Enhance Oncolytic Virus Function (#259)

Ryann C. Guayasamin

Nuclear Factor-kappa B1 is a critical regulator of mature B cell homeostasis and serves to prevent chronic inflammatory disease. (#65)

TGF-β dependent immunoregulatory function of GARP (#66)

Functional Promiscuity in C-terminal Peptidic C3aR/C5a1 Ligands (#260)

Integrin CD11b attenuates DSS-induced colitis by promoting TLR-triggered IL-10 expression in macrophages via Src / Akt pathway (#67)

Predictive markers for the detection of antibody-mediated rejection in kidney transplantation : Procalcitonin and CH50 (#68)

IL-6 and CH50 for monitoring of disease activity in systemic lupus erythematosus (#69)

The generation of Tregs and IL-10/TGF-β-modified macrophages by docosahexaenoic acid via TGF-β dependent mechanism suppresses atopic dermatitis (#70)

Anti-inflammatory effect of diphlorethohydroxycarmalol (DPHC) isolated from lshige okamuarae in vitro & in vivo (#71)

Critical role for post-transcriptional regulation of the gene encoding the key inflammasome protein NLRP3 (#72)

Moritz Haneklaus

Enhanced in vivo efficacy using a novel long-life type I Interferon variant in a mouse model of multiple sclerosis (#73)

Serum cytokines in patients with moderate and severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) (#74)

Sharni L Hardcastle

Antagonism of STAT3 signaling by lyssaviruses: a potent mechanism to inhibit cytokine responses, and potential target for antivirals (#263)

Angela Harrison

A variant of IFNλ4 displaying decreased activity is associated with better hepatitis C virus clearance and reduced ISG expression (#75)

Regulation of activins and the activin-binding protein, follistatin, by Toll-like receptor ligands in the adult mouse (#76)

S100 proteins regulate LPS-induced inflammation in murine lung (#79)

Human airway epithelial cells express ABCC4/MRP4, a transporter for uric acid and cAMP secretion, that contributes to innate and adaptive immune responses. (#265)

Jeremy A Hirota

IFN-lambda production of CD8 cDCs in response to DNA-viruses, transfected dsDNA or cyclic-di-nucleotides depends on STING (#266)

Hubertus Hochrein

Loss of IRF9 prevents lethal lymphocytic choriomeningitis virus infection in mice at the cost of viral persistence and chronic inflammation in the CNS (#80)

Critical role of PKR in antiviral stress granule and IFN-β enhanceosome formation, and is impaired in chronic obstructive pulmonary disease. (#81)

Enhanced PI3K activity leads to decreased IFN-β response to influenza infection in chronic obstructive pulmonary disease (#82)

S100A8 is induced in macrophages by oxidants and modulates redox responses in inflammation (#83)

Differential responses to and regulation of gp130 cytokines in astrocytes versus microglia (#84)

Meng-Ping MP Hsu

Identification of novel hydrogen sulfide (H₂S) donors with controlled release rates that elicit anti-inflammatory effects in RAW264.7 cells (#85)

Common gamma chain induced STAT5 binding to Mcl1 is essential for innate lymphocyte development (#88)

Nicholas D Huntington

Effect of Plantago major extract on plasma cytokine changes in paracetamol-induced liver injury (#89)

Identification and functional characterization of K+ transporters encoded by Legionella pneumophila kup genes. (#268)

Juliana I. Hori

Examination of inflammatory pathway induction in the fruit bat. (#269)

Regulation of cell survival signals by Interleukin-3 in myeloid cells (#270)

LEGENDplex™, A New Multiplex Solution for Cytokine and Chemokine Quantification in Biological Samples (#90)

An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression (#271)

Type I interferon-mediated host response against viral infection in the absence of STAT1 (#91)

Functional expression of umami taste receptor T1R1/T1R3 in mouse neutrophils (#272)

Cytokine-induced tumor suppression: a GRIM lesson (#274)

Dhan Kalvakolanu

The IL-3 receptor α subunit N-terminal domain: role in receptor assembly and signalling (#276)

Interleukin-10 is critical for the protection of mice from lethality by lung infection of Acinetobacter baumannii (#92)

Re-Zincing the macrophage antimicrobial response to Salmonella typhimurium. (#277)

Ronan Kapetanovic

A viral sensor MDA5 and autoimmune diseases (#94)

Sex-differences in classical monocyte recruitment during inflammation (#95)

Suppressor of cytokine signalling (SOCS) 5 regulates the innate anti-viral responses to influenza A infection. (#278)

Lukasz Kedzierski

PD-L1^hi B regulatory cells are critical for control of the humoral immune response (#96)

TNF-induced pain requires local colony-stimulating factor (CSF)-1 signalling and systemic neutrophil infiltration (#98)

Differential effects of pro-inflammatory cytokines IL-1β and TNFα on cell adhesion molecules in an in vitro model of the human blood-brain barrier. (#279)

Modulation of Dendritic Cell IL-6 and TNF-α Production in an In Vitro Model of Red Blood Cell Transfusion (#99)

Effects of caffeic acid phenethyl ester on Prevotella intermedia lipopolysaccharide-induced production of proinflammatory mediators in murine macrophages (#280)

Suppressors of Cytokine Signalling (SOCS) 1 and SOCS3 coordinate regulation of macrophage polarization (#281)

Tatiana B Kolesnik

Cell crowding induces interferon regulatory factor 9 which confers resistance to chemotherapeutic drugs (#282)

Iryna Kolosenko

IL-1-Induced Production of Chemokines CCL5 and CXCL10 requires K63-linked Polyubiquitination of IRF1 (#283)

Anti-Arthritic Activity of Petroleum Ether Fraction of Celastrus paniculatus willd. Seeds. (#100)

Pankaj Kothavade

Successful combined intra-tumoural immunotherapy of established murine mesotheliomas requires B cell involvement (#101)

Shruti Krishnan

Immuno-stimulatory effect of Lactobacillus plantarum HY7712 via Toll-like Receptor 2 Signaling Pathway (#102)

Identification of a novel interferon-stimulated gene whose product significantly restricts retrovirus replication (#103)

Negative regulation of IL-1β through the PI3K pathway is mediated by Akt-dependent inactivation of FoxO1 in TIR-stimulated mast cells (#104)

The role of IFN-γ and IL-27 for Th17 plasticity in mouse CNS inflammation (#105)

Florian C Kurschus

Gain of Glycosylation in MSMD Patients Reveals the Key Role of Galectins and Lipid Nanodomains in IFN-γ Receptor Assembly and JAK/STAT Signaling (#106)

Christophe Lamaze

Identification of a novel low molecular weight inhibitor targeting macrophage migration inhibitory factor (MIF). (#284)

Shedding light on preterm immunity (#285)

Chun Wang Jason Lao

Inhibitor of apoptosis (IAP) proteins repress spontaneous inflammatory joint disease (#286)

The role of nucleotide-binding oligomerization domain 1 (Nod1) in cytokine production by macrophages in response to Mycobacterium tuberculosis (#108)

Granulocyte macrophage-colony stimulating factor and interleukin-3 are not essential for endotoxin-induced extramedullary myelopoiesis (#109)